Description

The Position

2025 Summer Intern - Biology Research | AI Development

Department Summary

At Genentech Research & Early Development (gRED) we have initiated an exciting journey to bring together and further strengthen our computational talent and capabilities by forming a new, central organization - gRED Computational Sciences (gCS). gCS is on a mission to partner across the organization to realize the potential of data, technology and computational approaches that will revolutionize how targets and therapeutics are discovered and developed, ultimately enabling novel treatments for patients across the world. We stand at the beginning of this exciting journey.

BRAID (Biology Research | AI Development) is a department within gCS that focuses on developing and applying machine learning methods to impact biological discovery, with the ultimate goal of impacting drug discovery and human health. We work collaboratively across disciplines both within and outside gCS.

We are searching for a motivated summer intern to work on designing, developing, and interpreting ML models of DNA and RNA to improve our understanding of gene regulation, predictions of common disease variants and genome engineering. The candidate will further our work on sequence modeling approaches that can be used to advance programs in gene and cell therapy.

This internship is located in South San Francisco, CA, on-site.

The Opportunity

• The intern will train or fine-tune models of DNA/RNA sequence on disease relevant genomics data, such as single-cell ATAC-seq, MPRA, ChIP-seq
  
• Interpret and evaluate ML models of regulatory DNA or RNA
  
• Contextualize and predict the impact of edits in the genome sequence using ML models
  

Program Highlights

• Intensive 12-weeks, full-time (40 hours per week) paid internship.
  
• Program start dates are in May/June 2025.
  
• A stipend will be provided to help alleviate costs associated with the internship.
  
• Ownership of challenging and impactful business-critical projects.
  
• Work with some of the most talented people in the biotechnology industry.
  

Who You Are (Required)

Required Education:

• You must be pursuing a PhD (enrolled student)
  

Required majors: Bioengineering, Computer Science or Engineering, Data Science or related fields.

Required Skills:

• Experience with popular regulatory genomics models such as Borzoi, Enformer or BPnet; DNA/RNA language models; or models of RNA activity.
  
• Proficiency in Python and experience with frameworks for machine learning inference (e.g. Pytorch, TensorFlow, Lightning).
  
• Familiarity with fundamental ML concepts and interpretation techniques such as transformers, saliency maps, DeepLIFT/DeepSHAP.
  
• Previous educational exposure to basic concepts in cell biology and gene expression.
  

Preferred Knowledge, Skills, and Qualifications

• Excellent communication, collaboration, and interpersonal skills.
  
• Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.
  

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is $50.00 per hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.