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UT Southwestern Medical Center
Dallas, TX, United States
2 days ago
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UT Southwestern Medical Center
Dallas, Texas, United States
2 days ago


Postdoctoral Fellowship in Subcellular Signaling, Development and Cancer

Job description:

Two postdoctoral positions are immediately available in Saikat Mukhopadhyay’s laboratory in Dept. of Cell Biology to study the role of cilia-generated signaling in development and disease. 

We utilize a variety of biochemical, cell biological and reverse genetic approaches to understand signaling mediated by cilia and dissecting their role during normal development and disease. The primary cilium was long mistaken as a vestigial appendage, despite being the first cellular organelle to be described in biology. Cilia are now considered as vital sensory organelles for detection and transmission of a broad range of chemical and mechanical signals in most cells. However, studying signaling by cilia has been challenging due to the minute size of these compartments and lack of good models. We have pioneered multiple paradigms in studying cilia in development and disease using mouse models targeting trafficking to cilia and signaling by cilia. These paradigms instruct us about developmental programs, previously unknown phenotypic outcomes, and new ways to understand and target diseases such as polycystic kidney disease, pediatric cancers such as medulloblastoma, and congenital disorders such as neural tube defects.  

Key questions remain on how compartmentalized signaling by cilia integrates developmental processes from subcellular to meta scales. Going forward, we are now in a unique position to translate our understanding in ciliary trafficking and signaling in multiple contexts including: (a) studying core trafficking mechanisms in ciliary biogenesis and signaling, (b) designing drugs targeting ciliary trafficking in polycystic kidney disease, (c) targeting the cilia-centrosomal complex in medulloblastoma, and (d) targeting neural tube defects from high hedgehog signaling.

A relatively recent video describing these projects is at:

Featured publications can be found at:

Please also check out unpublished projects in ASCB talks in Minisymp 15 on Emerging Systems (M85, 11:30 EST, Thursday 9th Dec), Special interest subgroup on Staging of the Centrosome-Cilium Complex for Inside-Outside Cellular Signaling (SG263, Friday 10th Dec 3:00 EST), and two posters (P1070 and P1124 on Saturday Dec 11th ). Saikat will also co-chair the Minisymp 24 on Multiplexed Analysis of Signaling in Diverse Tissue Architectures (Friday Dec 10th 11:30 am EST).


Candidates must have a recent Ph.D. or M.D./Ph.D., with less than five years of prior postdoctoral experience, and a demonstrated research record with at least one first author publication. Preference will be given to applicants with a strong background in cell and molecular biology, mouse genetics or structural/chemical biology. UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.

Our lab dictum is as follows: Work hard, dream big, aim high, but be grounded in reality. We are a closely-knit group of scientists with diverse sets of expertise and passionate about solving the particular biological problem, often embarking on newer methods and paradigms as necessary. We utilize a variety of high-quality core services inside and outside UT Southwestern that enables us to address a biological problem using expertise from various fields. Thus, the postdoctoral fellow will be well supported but needs to work independently and also be comfortable in working collaboratively in a group. The vibrant and collegial scientific atmosphere in Cell Biology department and in UT Southwestern will also be a catalyst for professional growth.

Job Information

  • Job ID: 60117054
  • Location:
    Dallas, Texas, United States
  • Position Title: Postdoctoral Fellow
  • Company Name: UT Southwestern Medical Center
  • Industry: Medical
  • Job Function: Research
  • Job Type: Full-Time
  • Min Education: Ph.D.

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