Description
A postdoctoral fellow is sought to continue our work on deciphering the mechanism of nucleocytoplasmic transport using 3D single molecule fluorescence microscopy and single particle tracking approaches (see Sau et al., 2025 Nature 640:821). Both astigmatism and MINFLUX microscopy on local instruments will be applied to determine the binding locations of various proteins within the nuclear pore complex (NPC), the locations of various transport pathways though the pore, and the structural and dynamic properties of the FG-polypeptides, which generate the permeability barrier.
Requirements
The successful applicant will purify his/her own reagents and perform the single molecule experiments.
Required Experience:
Single molecule fluorescence methods, quantitative approaches.
An interest in method development is essential.
Desirable Experience:
Biochemical and biophysical methods and approaches, standard molecular biology and protein chemistry techniques, image analysis, CRISPR/Cas and/or computational simulations.
Formal training can range from physics to cell biology.
The ideal candidate will be organized, highly-motivated and will be able to work independently.
Interested individuals should send a cover letter, CV and the names and contact information for 3 references to:
Professor Siegfried Musser
Department of Cell Biology and Genetics
College of Medicine
Texas A&M University
206 Olsen Blvd.
College Station, TX 77845
smusser@tamu.edu
https://musserlab.medicine.tamhsc.edu
Salary commensurate with experience.
